Zika Virus: A Comprehensive Overview
Introduction
The Zika virus (ZIKV) is an illness
spread by mosquitoes and became a major topic all over the world because it
caused many birth defects, particularly microcephaly. Uganda was where the
first case of the virus was seen in 1947, but it didn’t become widely known
until there were big outbreaks in the Pacific and the Americas in 2015–2016. The
World Health Organization (WHO) stated in 2016 that Zika was a worldwide health
emergency and could cause a great deal of harm.
It covers the history, ways to get
infected, basic symptoms, medical diagnosis, how it can be treated, prevention
and worldwide effects of the Zika virus.
1. History and
Origin of the Zika Virus
The first case of the Zika virus was
found in the Zika Forest of Uganda in 1947 when researchers were working on
yellow fever. The virus was first found in a rhesus monkey by scientists and it
was later seen in Aedes africanus mosquitoes in 1948. In 1952, the first people
who got the illness were reported in Uganda and Tanzania.
Zika infections were not common and
were usually light for many years, with only a few outbreaks in Africa and
Southeast Asia. In 2007, Yap Island in Micronesia experienced a huge outbreak,
the first time the disease spread widely outside Africa and Asia. The virus
appeared in French Polynesia in 2013 and experts observed a rise in cases of
Guillain-Barré syndrome (GBS) and other neurological disorders.
The largest outbreak happened in
Brazil in 2015 and Zika was identified as the reason for a significant increase
in microcephaly among newborns. Because of this, people around the world became
concerned which caused widespread research and public health actions.
2. Transmission
of the Zika Virus
Zika virus is mostly spread in these
ways:
A. Mosquito
Vectors
Most cases are carried by Aedes
mosquitoes such as:
·
Most commonly,
the species Aedes aegypti.
·
Asian tiger
mosquito (Aedes albopictus)
They are very active during the day
and prefer warm places close to the equator.
B. Non-Mosquito
Transmission Routes
1. Mother-to-Child (Congenital Transmission) – A virus can be transferred from a pregnant
woman to her fetus which can lead to severe problems during birth.
2. Through Sex – Zika infection can take place through
unprotected sexual contact with an infected person, even if they look healthy.
3. Blood Transfusion – There have been instances where people
received Zika from contaminated blood.
4. In the laboratory – There have been rare reports of people being
infected while doing research.
3. Symptoms and
Clinical Manifestations
Most people who get Zika virus (around
80%) show no symptoms. When an infection appears, the symptoms are usually mild
and last for 2–7 days. Most people experience symptoms like:
·
Fever
·
Often, a rash is
called maculopapular.
·
Pain in the
joints, especially those found in the hands and feet
·
Sometimes,
conjunctivitis (also called red eyes)
·
Muscle pain
·
Headache
Severe
Complications
Zika is usually only mild, though it
has also been tied to serious neurological problems.
A. Birth defects
caused by Zika in babies (including microcephaly)
·
Small head and
brain (known as microcephaly).
·
Brain
calcifications
·
Problems with
vision and hearing
·
Limb contractures
·
Developmental
delays
B. Guillain-Barré
Syndrome (GBS)
·
A condition that
occurs when the immune system attacks nerves which results in muscles weakening
and becoming paralyzed.
·
Sometimes, it
needs high levels of medical care such as the use of ventilators for severe
cases.
4. Diagnosis of
Zika Virus
A diagnosis is formed using the
following:
A. Assessing
through Clinical Means
·
A person has
symptoms or has been to areas where the virus is found.
B. Tests
Conducted in a Lab
1. RT-PCR (Reverse Transcription Polymerase Chain
Reaction) is used to detect viral RNA in blood, urine or semen (especially in
the first week after infection).
2. Serology (IgM Antibody Test) detects
antibodies in the blood but sometimes may react with dengue or yellow fever, so
the test results can be inaccurate.
3. Prenatal Testing – Doctors use ultrasound and
amniocentesis to detect problems with the fetus during pregnancy.
5. Treatment and
Management
There isn’t a particular antiviral
drug designed to fight Zika. The main aim of management is to:
·
Take steps to
manage symptoms (like rest, stay hydrated, use acetaminophen for pain).
·
Don’t take NSAIDs
(e.g., aspirin, ibuprofen) until it is certain that dengue is not present (to
avoid bleeding).
·
Keeping an eye
out for any problems or difficulties (in pregnant women and GBS cases).
Scientists are still testing potential
vaccines and antiviral drugs, but there are not any available yet.
6. Prevention and
Control Measures
Because there is no vaccine, the main
way to prevent Zika is:
A. Mosquito
Control
·
Getting rid of
any areas where water can collect and stagnate (in containers, tires or flowerpots).
·
Applying insect
repellents (DEET, picaridin or oil of lemon eucalyptus).
·
Wearing clothing
that covers the arms and legs (long sleeves and pants).
·
Putting up both
window screens and bed nets.
B. Sexual
Transmission Prevention
·
You should either
not have sex for 3 months (men) or 2 months (women) after being exposed to Zika
or always use a condom.
C. Travel
Precautions
·
Pregnant women
should postpone any travel to places with Zika.
·
Having a test for
Zika when returning from places where it is common.
D. Public Health
Strategies
·
Prompt
surveillance and fast actions for outbreaks.
·
Teaching the
public about controlling mosquitoes.
7. Global Impact
and Outbreaks
In the Americas, the 2015–2016
epidemic was bigger than any other recorded outbreak.
·
Brazil recorded
more than 200,000 cases and 20 times the normal number of microcephaly cases.
·
There was broad
transmission of the disease in Colombia, Venezuela and Central America.
·
Authorities in
the United States found cases involving travelers and only a little spreading
in Florida and Texas.
Zika cases were reduced in 2017
because of herd immunity and mosquito control, although the threat is still
there in tropical areas.
8. Current
Research and Future Directions
·
Vaccine
Development – Several
vaccines are being tested in clinical trials (such as DNA-based and
live-attenuated vaccines).
·
Antiviral
Drugs – Scientists are testing drugs that
stop viruses from multiplying.
·
Genetic
Mosquito Control – Testing
Wolbachia-infected or modified mosquitoes to cut down on the number of Aedes
mosquitoes.
Conclusion
There is still a major health concern
from the Zika virus in areas with Aedes mosquitoes. Even though the 2015–2016
pandemic ended, it can still return. Controlling mosquitoes, using safe sexual
practices and traveling wisely are very important. Research into vaccines and
treatments should continue to protect against more outbreaks.
It is important for people and
countries to stay aware and cooperate, mainly to help protect women who are
pregnant and their unborn children from Zika.
Sources (Use WHO,
CDC and peer-reviewed journals to provide references for the full article.)
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